Targeted Nanoparticles Eliminate Aging Retinal Cells to Reverse Vision Decline

Abstract Sensitive cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression. Eliminating senescent RPE cells has shown therapeutic potential, but conventional senolytics often lack the specificity required to spare non-senescent cells, raising safety concerns. To overcome this, we performed integrated transcriptomic analyzes of male mouse-derived RPE cells under natural aging and chemically induced senescence conditions. These analyzes identified Bst2 as a membrane-localized marker selectively upregulated in senescent RPE cells, with minimal expression in young controls. Based on this discovery, we developed a modular, antibody-pluggable drug delivery platform–BZ-PON–comprising mesoporous silica nanoparticles functionalized with a recombinant Fc-binding domain and conjugated with anti-Bst2 antibodies. This nanocarrier selectively accumulates in Bst2-expressing senescent RPE cells, enabling targeted drug delivery and sparing healthy retinal cells. In vivo administration of ABT-263-loaded BZ-PON in aged and senescence-induced retinal degeneration models resulted in the selective ablation of senescent cells, restoration of RPE function, and improved visual outcomes. Together, our study integrates senescence-specific marker discovery with precision nanomedicine, establishing a versatile platform for targeted senotherapy. These findings offer a promising therapeutic approach for retinal aging disorders, such as age-related macular degeneration. A collaborative team of researchers from UNIST and Konkuk University College of Medicine has introduced an innovative nanotechnology platform that precisely targets and removes aging retinal cells, leading to partial restoration of vision in mouse models. This advancement opens new possibilities for treating age-related macular degeneration (AMD), a leading cause of blindness worldwide. As the global population ages, the incidence of AMD continues to rise, damaging the central retina and impairing vision. Current treatments primarily address symptoms but do not fundamentally halt disease progression. The new platform specifically eliminates senescent retinal pigment epithelium (RPE) cells—cells that, when aged, secrete harmful substances that exacerbate retinal degeneration. Led by Professor Ja-Hyoung Ryu from the Department of Chemistry at UNIST and Professor Hyewon Chung from the Department of Ophthalmology at Konkuk University College of Medicine, the research team developed mesoporous silica nanoparticles functionalized with antibodies targeting Bst2, a protein uniquely overexpressed on the surface of senescent RPE cells. These nanoparticles deliver a potent senolytic drug, ABT-263, directly into the aged cells. Once inside, they release the drug, inducing cell death while sparing healthy tissue. The design also ensures safety: even if nanoparticles bind to normal cells, they remain inactive unless exposed to the high-glutathione environment characteristic of senescent cells. In vivo experiments demonstrated that intravitreal injection of these drug-loaded nanoparticles selectively removed senescent cells without harming healthy tissue, resulting in significant improvements in retinal electrical responses and partial recovery of visual function in mice. Professor Chung emphasized, “Our targeted approach addresses the disease at its root, moving beyond symptom management. This could revolutionize treatment for dry AMD and other age-related degenerative conditions.” Professor Ryu added, "By identifying a novel marker and engineering targeted nanocarriers, we have paved the way for highly specific therapies that can be adopted to other age-related diseases by simply changing the targeting antibody." The findings of this research were published in Nature Communications on March 18, 2026. This study has been supported by the Ministry of Science and ICT (MSIT), the National Research Foundation of Korea (NRF), and the Korean ARPA-H Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare (MOHW). Journal Reference Jun Yong Oh, Jae-Byoung Chae, Hyo Kyung Lee, et al., “Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells,” Nat. Commun., (2026).

2026.04.15

Turning Solar Panel Waste into Hydrogen and High-Value Silica

Summary Although Earth’s abundant silicon (Si) is thermodynamically reactive with water to produce hydrogen (H2) and silicon oxide (SiO2, silica), the Si-water reaction is kinetically self-limited by the silica passivation layer that spontaneously forms on Si surfaces. If this limitation of the Si-water reaction can be overcome, hydrogen (H2) can be directly produced from water. Here, we demonstrate that “dynamic” mechanochemistry can overcome the self-limitation of the Si-water reaction, without using corrosive additives, to reach the theoretical limit. As one real-world application, upcycling end-of-life silicon solar panels was performed, with techno-economic analysis suggesting the strong competitiveness of the proposed method for the Si-water reaction. High-purity hydrogen (∼100%) gas and solid silica as a value-added product were produced under a separation-free process. In response to the growing accumulation of end-of-life solar panels, researchers at UNIST have unveiled an innovative, environmentally friendly method to convert photovoltaic silicon into high-purity hydrogen and valuable silica. Led by Professor Jong-Beom Baek from the School of Energy and Chemical Engineering at UNIST, this breakthrough promises to revolutionize solar panel recycling and sustainable hydrogen production. The team led by Professor Jong-Beom Baek developed a mechanochemical process that overcomes the self-limiting silica passivation layer on silicon surfaces. By placing silicon and water with small abrasive beads into a rotating vessel, repeated mechanical collisions strip the silica layer, enabling the reaction to proceed to nearly its theoretical maximum. Experimental results show approximately 1,706 mL of hydrogen per gram of silicon—achieving 99.6% of the maximum yield, significantly surpassing conventional thermochemical methods. Moreover, the silica byproduct serves as an effective catalyst support. When used with nickel catalysts, it enhances carbon dioxide conversion and methane selectivity, thanks to its high surface hydroxyl density that improves catalyst dispersion. “By leveraging waste silicon from decommissioned solar panels, our process produces high-purity hydrogen efficiently while also recovering valuable silica for industrial applications,” says Professor Jong-Beom Baek. “This approach not only advances sustainable energy but also contributes to resource circularity and environmental protection.” This technology offers a cost-effective, scalable, and environmentally benign alternative to traditional photovoltaic waste management. Operating continuously, the process boasts higher productivity and energy efficiency, making it suitable for industrial deployment. It paves the way for a circular economy in solar energy, transforming waste into valuable resources and supporting the global shift toward clean hydrogen. The findings of this research were published in the online version of Joule on March 27 and were highlighted in the journal's Future Energy section. The study has been supported by the Ministry of Science and ICT (MSIT) and the National Research Foundation of Korea (NRF). Journal Reference Changbeom Jeon, Hyejin Lee, Ga-Hyeun Lee, et al., "Simple oxygen doping strategy for highly porous carbon fibers enabling ultrafast and efficient iodine capture," Chem. Eng. J., (2026).

2026.04.14

New Study Unveils High-Performance Porous Carbon Fiber for Rapid Removal of Radioactive Iodine

Abstract The effective removal of nuclear waste from fission has attracted significant attention, with numerous porous sorbents reported in recent decades. The practical application of current sorbents is often hindered by limited removal efficiency and low production scalability. Here, we developed activated carbon fibers (ACFs) as an ultrafast and effective iodine capture material using a scalable method. The engineered ACFs possess and extraordinary micro/mesoporous structure with a surface area exceeding 2900 m2 g−1 while maintaining mechanical and thermal stability. The resulting fibers demonstrate a superior iodine capture capacity of 3.10 g g−1 and a capture rate of 2.76 g g−1 h−1. To further augment these properties, a novel oxygen-doping strategy was implemented. This approach dramatically improves performance, achieving 51% higher capacity (4.68 g g−1) and 76% faster rate (4.86 g g−1 h−1). Notably, exfoliation reactions of iodine within carbon layers that induced structural changes were discovered. Our work underlines the promise of ACFs for nuclear waste management. A joint research team, led by Professors Han Gi Chae and Seung Geol Lee from the Department of Materials Science and Engineering at UNIST has unveiled a novel, ultra-porous carbon fiber capable of quickly capturing radioactive iodine gases—a critical challenge in nuclear waste treatment and environmental safety. This scalable material demonstrates exceptional adsorption capacity and speed, with potential applications in nuclear facilities and emergency response. The engineered carbon fibers feature an extraordinary surface area exceeding 2,980 m² per gram, thanks to a manufacturing process that creates diverse pore sizes and incorporates oxygen doping. This structure enables the fibers to adsorb up to 4.68 grams of iodine per gram—over 1.5 times higher than conventional materials—and reach saturation within approximately 100 minutes. The oxygen doping enhances the chemical interaction with iodine, further boosting performance by 51% in capacity and 76% in adsorption rate. Additionally, the fibers maintain over 90% of their initial capacity after multiple reuse cycles, supporting cost-effective, large-scale deployment. The fabrication process is straightforward and cost-efficient, avoiding complex shaping steps typical of other materials like metal-organic frameworks (MOFs), making mass production feasible. Professor Han Gi Chae explains, “Our findings reveal the dynamic structural changes during iodine adsorption, providing new insights into how porous carbon materials interact with hazardous gases. This advancement could revolutionize safety measures in nuclear waste management and environmental remediation.” This innovative material offers a practical, scalable solution for rapid iodine removal, essential for nuclear safety and environmental protection. Its ease of production and reusability pave the way for widespread application in nuclear facilities, accident response systems, and pollutant treatment. The findings of this research have been published in Chemical Engineering Journal on April 1, 2026. The study has been supported by the Ministry of Trade, Industry and Energy (MOTIE), the Korea Planning & Evaluation Institute of Industrial Technology (KEIT), and the Ministry of Science and ICT (MSIT). Journal Reference Changbeom Jeon, Hyejin Lee, Ga-Hyeun Lee, et al., "Simple oxygen doping strategy for highly porous carbon fibers enabling ultrafast and efficient iodine capture," Chem. Eng. J., (2026).

2026.04.13

UNIST Unveils AI-Driven Framework for Real-Time Multi-Pollutant Air Quality Monitoring

Abstract Simultaneous prediction of multiple air pollutants is essential for quantifying human co-exposure and evaluating the health impacts of pollutant mixtures. However, spatial and temporal gaps in geostationary satellite observations, chemical transport models, and ground-based monitoring networks hinder accurate hourly assessments of multi-pollutant dynamics. Here, we present Deep Learning for Multiple Air Pollutant analysis (DeepMAP), a deep learning framework that simultaneously predicts six major air pollutants─PM10, PM2.5, O3, NO2, CO, and SO2─at hourly resolution. DeepMAP demonstrated robust performance across multiple pollutants and generalized well to unseen regions. The framework accurately captured dynamic high-concentration co-pollution episodes during March 2021, with normalized RMSE values below 0.36 for all pollutants. DeepMAP revealed that PM10-PM2.5 co-exceedance was the most frequent across East Asia (91 days/year), followed by PM10-PM2.5-NO2 (42), PM2.5-O3 (18), and PM10-PM2.5-O3 (12). Hotspots for PM10-PM2.5-NO2–O3 co-exceedance were identified over the North China Plain, East China, and South Korea, where the regional annual totals reached 24, 19, and 15 days, respectively. A novel co-exposure index further identified three distinct hotspot regions where the contribution of NO2 was approximately twice that observed elsewhere. Our findings provide a high-resolution, data-driven framework for characterizing multi-pollutant co-exposure and identifying regional priorities for air quality management and public health protection. A research team, led by Professor Jungho Im from the Department of Civil, Urban, Earth, and Environmental Engineering at UNIST, has introduced DeepMAP, a cutting-edge artificial intelligence model that accurately estimates hourly levels of six key air pollutants across East Asia. The technology, developed from 2021 to 2023, provides new insights into the widespread and simultaneous exceedance of air quality standards, with significant implications for health policies and environmental management. DeepMAP integrates diverse data sources—including geostationary satellite imagery, atmospheric chemical transport models, meteorological data, and ground observations—to produce real-time, high-resolution maps of PM10, PM2.5, O₃, NO₂, SO₂, and CO. Operating at a 10 km spatial resolution and providing hourly predictions, the model captures dynamic pollution patterns and hotspots, revealing that Korea experiences about 15 days per year with four pollutants exceeding WHO safety thresholds simultaneously. Unlike traditional methods that estimate pollutants individually, DeepMAP’s multi-task learning approach models interactions among pollutants, significantly enhancing estimation accuracy. “By accurately capturing the complex interplay of multiple pollutants in real time, our model offers a powerful tool for assessing exposure risks and guiding effective policy decisions,” said Professor Jungho Im, lead researcher. “This represents a major step toward more realistic and comprehensive air quality management.” The study underscores the health risks posed by combined pollutant exposure, which can worsen respiratory and cardiovascular diseases. Traditional monitoring methods often fall short in providing detailed, regional, and real-time data. DeepMAP’s capabilities open new avenues for environmental monitoring, public health research, and proactive policymaking, especially during pollution episodes driven by seasonal phenomena like dust storms and high-pressure systems. The findings of this research have been published in Environmental Science & Technology on March 20, 2026. The study has been supported by the National Institute of Environmental Research (NIER) under the Ministry of Environment (ME), and by the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (MSIT). Journal Reference Eunjin Kang, Sihun Jung, Jungho Im, et al., "Quantifying Multi-pollutant Co-exposure via Deep Learning-Based Simultaneous Prediction Using Geostationary Satellite Data," Environ. Sci. Technol., (2026).

2026.04.10

Sea Surface Temperature Shifts in the Pacific Improve Year-Ahead Winter Climate Predictions

Abstract The winter North Atlantic Oscillation (NAO) is a dominant mode of climate variability affecting temperature and precipitation across the Northern Hemisphere, yet its prediction at seasonal-to-decadal (S2D) lead times remains challenging. Here, using multi-year hindcasts from a multi-model ensemble initialized on 1 November for 1962–2019, we show that NAO skill one year ahead improves significantly when the El Niño–Southern Oscillation (ENSO) undergoes a phase transition next year. This improvement is linked to the northward propagation of anomalous atmospheric angular momentum, which dynamically organizes the NAO and is captured in reanalysis and models. During ENSO transition years, prediction skill increases with ensemble size, and when more than 10 members are used, the forecasts display the signal-to-noise paradox. These findings highlight the potential for enhanced one-year NAO predictability when ENSO transitions are present and large ensemble sizes are used in S2D prediction systems, given the skillful prediction of ENSO phase transitions at one-year lead times by multi-model ensembles. A research team, affiliated with UNIST, in collaboration with the UK Met Office Hadley Centre, has identified that major changes in the equatorial Pacific’s sea surface temperatures—such as transitions between El Niño and La Niña—significantly boost the accuracy of winter weather forecasts in the Northern Hemisphere. Led by Professor Myong-In Lee in the Department of Civil, Urban, Earth, and Environmental Engineering, their findings mark a breakthrough in understanding how tropical Pacific variability influences mid-latitude climate prediction. The study reveals that during ENSO transition years, the correlation coefficient for NAO prediction improves markedly—up to 0.60—compared to near-zero correlations in stable ENSO years. This phenomenon occurs because the oceanic temperature changes trigger atmospheric angular momentum shifts that gradually propagate northward, affecting the NAO pattern approximately one year later. The process involves the interaction of delayed effects—initiated by sea surface temperature anomalies—and the rapid transfer of atmospheric signals via Rossby waves, large-scale planetary waves influenced by Earth's rotation. “During ENSO transition years, the tropical ocean changes significantly influence the atmospheric circulation, strengthening the signals used for long-term forecasting,” explained Professor Myong-In Lee. “This understanding can help improve climate prediction models and support strategic planning in sectors like agriculture and energy.” These insights provide a crucial step toward enhancing Korea’s climate prediction capabilities and developing more accurate regional models. By understanding the dynamical mechanisms linking tropical Pacific variability to Northern Hemisphere winter patterns, researchers can improve forecasts for long-term climate variability, aiding disaster preparedness and resource management. This research was supported by the Korea Meteorological Administration and the National Institute of Meteorological Sciences, through projects focused on operational climate prediction systems and climate crisis response strategies. The findings of this research have been published in Nature Communications on March 25, 2026. The study has been supported by the Korea Meteorological Administration (KMA) and the National Institute of Meteorological Sciences (NIMS), through projects focused on operational climate prediction systems and climate crisis response strategies. Journal Reference Satyabrat Behera, Jong Sung Moon, Kirlie Iulius Figuera Michal, et al., "Electrical Control of Single Photon Emitters in WSe2 on a Si Nanopyramid Array with a Negligible Stark Effect," Nano Lett., (2026).

2026.04.10

New Study Unveils Mussel-Inspired Coating for Rapid Radioactive Surface Decontamination

Abstract Efficient and rapid decontamination of radioactive elements is important to prevent radioactive exposure. Herein, we develop a strippable catechol-terminated polyurethane (CPU) coating for effective surface decontamination. Our polyurethane coating can be directly applied to contaminated surfaces via simple spraying or solution casting, followed by rapid drying at room temperature. The resulting coating is easily stripped off with sufficient toughness and adhesion strength, showing superior 137Cs removal efficiency on stainless steel (∼94.9%) and rough cement (∼59.1%), in a much shorter time (<3 h) compared to commercial decontamination coatings (∼93.8% on stainless steel and ∼8.4% on cement after 24 h). This performance can be attributed to the strong adhesion and cohesion mediated by catechol moieties. Furthermore, after use, the coating waste is readily dissolvable in acetone, suggesting potential for reducing radioactive waste with the aid of an appropriate separation process, thereby preventing secondary contamination. These results establish CPU as a promising radioactive decontamination strategy. Professor Dong Woog Lee from the School of Energy and Chemical Engineering at UNIST, in collaboration with the Korea Atomic Energy Research Institute (KAERI) have unveiled a novel, mussel-inspired polyurethane coating capable of removing over 95% of radioactive cesium from surfaces in just three hours—far faster than existing methods. This breakthrough promises to enhance safety and efficiency in nuclear decontamination efforts. The innovative coating utilizes catechol groups—derived from mussel adhesion proteins—attached to polyurethane polymer chains, creating a highly adhesive surface. Applied onto contaminated surfaces, the coating dries within hours and can be peeled off like tape, effectively removing radioactive particles. Laboratory tests demonstrated a cesium removal efficiency of 94.9% on stainless steel and 13.1% on porous cement surfaces after two applications, outperforming commercial products that typically require 24 hours. Additionally, the coating can be dissolved in acetone post-use, enabling waste separation and reducing secondary contamination. Dr. Heeman Yang, lead researcher from KAERI, stated, “This technology offers a faster, more effective, and environmentally conscious approach to decontamination. Its ability to rapidly remove radioactive materials while facilitating waste management marks a significant advancement in nuclear safety.” This development addresses critical needs in nuclear facility decontamination, emergency response, and waste reduction. By combining speed, efficiency, and eco-friendliness, the coating holds promise for broad application in nuclear safety and environmental management, contributing to safer decommissioning and accident mitigation in the future. The findings of this research have been published online in the March 2026 issue of Materials Horizons. The study has been supported by the Institute of Civil Military Technology cooperation, funded by the Defense Acquisition Program Administration and the Ministry of Trade, Industry and Energy (MOTIE). Journal Reference Jae Seung Lee, Ye-won Jeong, Donghyun Kim, et al., "A strippable catechol-terminated polyurethane coating for large-area radioactive cesium decontamination," Mater. Horiz., (2026).

2026.04.09